Welcome to the WHIST Trial Website. WHIST – Wound Healing In Surgery for Trauma is a Randomised Controlled Trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limb. This study is funded by the National Institute of Health Research. As a potential patient you can find more information relating to your treatment options, download our Patient Information Sheet and contact the WHIST Trial Team if you have any questions. If you are an investigator or involved in the trial's research team you can navigate ‘For the Research Team’ pages for further information relating the WHIST Trial.
Prof Matthew Costa
(Chief Investigator)
Dr Marta Campolier
(Trial Manager)
- To quantify and draw inferences on differences in the rate of ‘deep infection’ of the lower limb in the 30 days after major trauma between standard dressing and NPWT.
- To quantify and draw inferences on observed differences in the Disability Rating Index and general health-related quality of life in the 6 months after the major trauma.
- To quantify and draw inferences on the quality of wound healing, using a validated, patient-reported assessment of the scar.
- To determine the number and nature of further surgical interventions related to the injury, in the first 6 months after the major trauma.
- To investigate, using appropriate statistical and economic analysis methods, the resource use, and thereby the cost effectiveness, of negative pressure wound therapy versus standard dressing for wounds associated with major trauma to the lower limbs.
- To quantify the long-term (five year) Disability Rating, rates of chronic neuropathic pain and Health-related Quality of Life in the same group of patients
The following outcome measures will be collected:
- Deep Infection; As per CDC definition (see Section 4.4)
- Disability Rating Index
- EQ-5D-5L
- Patient-reported assessment of scar
- DN4 Pain Questionnaire
- Complications
NEWS
24 March 2023: 5-Year follow up data has been collected.
July 2022: 4-year follow up data has been collected.
July 2021: 3-year follow up data has been collected.
31 October 2020 A new publication re classifying open fractures was released in the BJJ
31 July 2020 Cost-utility analysis of the two interventions was publish in BJJ
30 July 2020: 2-Year Follow Up data has been collected.
11 February 2020: Results of the study were published in JAMA. Check our summary for participants in here
27 June 2019: Results have been analysed and going to be published in the near future.
20 June 2019: 1-Year Follow Up data has been collected.
01 November 2018: All short term follow up data (up to 6 months post-surgery) has been collected.
18 April 2018: Recruitment is completed with a total of 1548 consented articipants.
RELATED LINKS
Read more about the WHIST Trial on the Oxford Trauma website. Available here.
To see the WHIST Trial on ISRCTN - primary clinical trial registry
click here.
To see the WHIST Trial on Oxford University Hospitals NHS Foundation Trust website
click here.
NIHR Journals Library - please access the article about the trial here.
