University of Oxford
Prof Matthew Costa
Dr Marta Campolier
31 July 2020 Cost-utility analysis of the two interventions was publish in BJJ
30 July 2020: 2-Year Follow Up data has been collected.
27 June 2019: Results have been analysed and going to be published in the near future.
20 June 2019: 1-Year Follow Up data has been collected.
01 November 2018: All short term follow up data (up to 6 months post-surgery) has been collected.
18 April 2018: Recruitment is completed with a total of 1548 consented articipants.
Read more about the WHIST Trial on the Oxford Trauma website. Available here.
To see the WHIST Trial on ISRCTN - primary clinical trial registry
To see the WHIST Trial on Oxford University Hospitals NHS Foundation Trust website
NIHR Journals Library - please access the article about the trial here.
- To quantify and draw inferences on differences in the rate of ‘deep infection’ of the lower limb in the 30 days after major trauma between standard dressing and NPWT.
- To quantify and draw inferences on observed differences in the Disability Rating Index and general health-related quality of life in the 6 months after the major trauma.
- To quantify and draw inferences on the quality of wound healing, using a validated, patient-reported assessment of the scar.
- To determine the number and nature of further surgical interventions related to the injury, in the first 6 months after the major trauma.
- To investigate, using appropriate statistical and economic analysis methods, the resource use, and thereby the cost effectiveness, of negative pressure wound therapy versus standard dressing for wounds associated with major trauma to the lower limbs.
- To quantify the long-term (five year) Disability Rating, rates of chronic neuropathic pain and Health-related Quality of Life in the same group of patients
The following outcome measures will be collected:
- Deep Infection; As per CDC definition (see Section 4.4)
- Disability Rating Index
- Patient-reported assessment of scar
- DN4 Pain Questionnaire