University of Oxford
Prof Matthew Costa
(Trial Administrative Coordinator)
- To quantify and draw inferences on differences in the rate of ‘deep infection’ of the lower limb in the 30 days after major trauma between standard dressing and NPWT.
- To quantify and draw inferences on observed differences in the Disability Rating Index and general health-related quality of life in the 6 months after the major trauma.
- To quantify and draw inferences on the quality of wound healing, using a validated, patient-reported assessment of the scar.
- To determine the number and nature of further surgical interventions related to the injury, in the first 6 months after the major trauma.
- To investigate, using appropriate statistical and economic analysis methods, the resource use, and thereby the cost effectiveness, of negative pressure wound therapy versus standard dressing for wounds associated with major trauma to the lower limbs.
- To quantify the long-term (five year) Disability Rating and Health-related Quality of Life in the same group of patients
The following outcome measures will be collected:
- Deep Infection; As per CDC definition (see Section 4.4)
- Disability Rating Index
- Patient-reported assessment of scar
Congratulations to the WHIST team at University Hospital Aintree for recruiting the 400th participant into the trial.
Congratulations to Coventry trial team for recruiting the highest amount of participants into the WHIST trial.
Read more about the WHIST Trial on the Oxford Trauma website. Available here.
To see the WHIST Trial on ISRCTN - primary clinical trial registry
To see the WHIST Trial on Oxford University Hospitals NHS Foundation Trust website
NIHR Journals Library - please access the article about the trial here.